Blockade of CNG channels abrogates urethral relaxation induced by soluble guanylate cyclase activation
نویسندگان
چکیده
In the present study, we have characterized the presence and distribution of cGMP-gated cationic channels (CNG) in the rat urethra as well as its putative role in the mediation of the nitrergic relaxation. Previous studies have shown the inhibition of the sheep urethral nitrergic relaxations by the CNG's inhibitor L-cis-diltiazem [1]. Also in the rat urethra, L-cis-diltiazem (50 M) inhibited nitrergic relaxations elicited by electrical field stimulation (EFS) of arginine-vasopresin (AVP)-precontracted urethral preparations (Figure 1A).
منابع مشابه
Presence of cyclic nucleotide-gated channels in the rat urethra and their involvement in nerve-mediated nitrergic relaxation.
We have addressed the distribution of cGMP-gated channels (CNG) in the rat urethra for the first time, as well as their putative role in mediating of the relaxation elicited by electrical field stimulation of nitrergic nerves. Functional studies have shown that specifically blocking CNG with L-cis-diltiazem leads to the rapid inhibition of urethral relaxation induced either by nitric oxide (NO)...
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